Potential Interactions Between Lithium, Propranolol, Prazosin, Lorazepam, and Lurasidone

Key Interaction Concerns

The combination of lorazepam with prazosin may enhance hypotensive effects and increase risk of falls, especially in older adults, according to the European Heart Journal 1
Lorazepam (Ativan) is a benzodiazepine that can cause additive CNS depression when combined with other CNS depressants, as reported in the European Heart Journal 1
No significant pharmacokinetic interaction is expected between lorazepam and lurasidone as lorazepam is primarily metabolized through glucuronidation, according to the European Heart Journal 1

Patients with cardiovascular disease may be at higher risk for adverse effects from these combinations, as stated in the Journal of the American College of Cardiology 2
Elderly patients are more susceptible to orthostatic hypotension with prazosin and CNS depression with lorazepam, according to the European Heart Journal 1
The American College of Cardiology recommends careful monitoring of patients with cardiovascular disease when combining these medications, although the specific guideline is not mentioned in this article, patients with cardiovascular disease may be at higher risk for adverse effects from these combinations 2