Paracetamol Dosing in Chronic Kidney Disease

Introduction to Paracetamol Use

• The American Society of Clinical Oncology recommends oral paracetamol 1g every 6 hours (maximum 4g/day) for chronic pain management, with regular scheduled dosing preferred over "as needed" dosing in patients with chronic kidney disease stage 3B 1

Practical Dosing Considerations

• The National Kidney Foundation suggests that paracetamol can be used without dose adjustment in patients with chronic kidney disease stage 3B, with a maximum daily dose of 4g 1