Trazodone-Induced Orthostatic Hypotension

Clinical Evidence and Guidelines

• The American Academy of Sleep Medicine guidelines note that trazodone is associated with significant risks, including orthostatic hypotension, in older adults 1
• Multiple guidelines identify trazodone as a common cause of orthostatic hypotension that should be discontinued or modified as first-line management, although this particular fact is from a less preferred source, a more preferred source is not available 2