Bempedoic Acid Dosing Guidelines

Standard Dosing Regimen

• The American College of Cardiology recommends a dose of 180 mg taken orally once daily, with or without food, for patients with no renal or hepatic impairment 1, 2
• The tablet should be swallowed whole, as directed by the American College of Cardiology 2

Combination Therapy Dosing

• When using the fixed-dose combination with ezetimibe, the American College of Cardiology recommends one tablet (180 mg bempedoic acid/10 mg ezetimibe) once daily 2
• If combining with bile acid sequestrants, the American College of Cardiology advises taking bempedoic acid either 2 hours before or 4 hours after the bile acid sequestrant 2

Critical Drug Interactions Affecting Dosing

• The American College of Cardiology recommends avoiding concomitant simvastatin >20 mg daily due to increased exposure risk 1, 2
• The American College of Cardiology also recommends avoiding concomitant pravastatin >40 mg daily due to increased exposure risk 1, 2

Monitoring Parameters During Treatment

• The American College of Cardiology suggests assessing serum uric acid before initiation and monitoring if symptoms of hyperuricemia occur, with a mean increase of 0.8 mg/dL expected 1, 2
• The American College of Cardiology advises monitoring for signs of tendinitis or tendon rupture and discontinuing immediately if tendon rupture occurs 1, 2
• The American College of Cardiology recommends monitoring liver function tests as clinically indicated 1, 2

Common Pitfalls to Avoid

• The American College of Cardiology recommends not adjusting the dose based on LDL-C response, as the dose is fixed at 180 mg daily regardless of lipid levels 1
• The American College of Cardiology advises not combining bempedoic acid with high-dose simvastatin or pravastatin due to increased exposure risk 1, 2