Guideline for Evaluation and Management of Low IgA, High IgG, Low IgM Immunoglobulin Pattern

Initial Diagnostic Approach

Functional Antibody Assessment

B‑Cell Quantification and Phenotyping

Pattern‑Specific Differential Diagnosis

Management Based on Functional Antibody Results

Normal Functional Antibody Responses

Impaired Functional Antibody Responses + Recurrent Infections

Additional Investigations

Key Clinical Pitfalls