Mounjaro and Libido Effects

Medications Affecting Libido

SSRIs cause decreased libido, orgasmic dysfunction, and erectile problems, with sexual dysfunction rates likely underreported in clinical trials 1
Paroxetine has the highest rates of sexual dysfunction among antidepressants 1
Alpha-1 blockers used for lower urinary tract symptoms do not affect libido, though they cause ejaculatory dysfunction 2
5-alpha reductase inhibitors (finasteride, dutasteride) cause reduced libido, erectile dysfunction, and ejaculation disorders 2
Beta-blockers and mineralocorticoid receptor antagonists can negatively affect libido and erectile function, according to the American College of Cardiology 3

Underlying chronic illness and hormonal abnormalities associated with obesity, diabetes, or liver disease can independently cause decreased libido 4
The American Association for the Study of Liver Diseases suggests that psychogenic causes, alcohol use, and other medications should be systematically evaluated 4

The American College of Cardiology recommends obtaining testosterone levels and thyroid function tests when a patient on tirzepatide reports decreased libido 4
The European Urology Association suggests reviewing all concurrent medications, particularly antihypertensives, antidepressants, and statins, when evaluating decreased libido 2
The Mayo Clinic recommends assessing for uncontrolled diabetes, cardiovascular disease, and metabolic syndrome as independent contributors to decreased libido 5