Ruta Graveolens Bioactive Compounds and Therapeutic Effects

Primary Active Components and Pharmacological Properties

Rutin (quercetin-3-O-rutinoside) is the principal bioactive compound in Ruta graveolens, responsible for many of its therapeutic effects, according to the Nutrition Research Reviews 1
Rutin exhibits potent antioxidant properties that help neutralize reactive oxygen species and prevent oxidative damage, as reported by the Nutrition Research Reviews 1, 2
Rutin possesses anti-glycation activity, inhibiting the formation of advanced glycation end products (AGEs) that contribute to aging and disease, as found in the Nutrition Research Reviews 1, 2

Rutin can trap reactive dicarbonyl species such as methylglyoxal (MGO) and glyoxal (GO) that promote inflammation, as stated in the Nutrition Research Reviews 1
Rutin increases resistance of LDL to high glucose and copper-mediated oxidation, according to the Nutrition Research Reviews 1
Rutin has been studied for its potential in treating diabetic complications by reducing AGE formation, as reported in the Nutrition Research Reviews 1