Praxis Medical Insights

Est. 2024 • Clinical Guidelines Distilled

Made possible by volunteer editors from the University of Calgary & University of Alberta

Last Updated: 8/26/2025

Treatment for Pepper Spray Exposure to the Eyes

Immediate Management

  • The American Heart Association recommends immediate irrigation with copious amounts of tap water for 15 minutes as first-line treatment for pepper spray exposure to the eyes 1, 2
  • Begin decontamination by irrigation immediately after pepper spray exposure to minimize eye damage 1
  • Use copious amounts of tap water for irrigation, continuing for 15 minutes 1
  • When performing irrigation, avoid contaminating the unaffected eye, other individuals, or surrounding areas 1
  • Some patients may need assistance keeping their eyelids open during irrigation 1

Alternative Irrigation Solutions

  • If immediately available, eye irrigation with normal saline, Ringer's lactate solution, or a commercial eye wash solution is reasonable 1, 3
  • Commercial eye irrigation solutions may result in less severe eye injury compared to other irrigation fluids 3
  • Balanced salt solutions may be more comfortable than other irrigation fluids 3

Special Considerations

  • Contact regional poison centers for expert advice on management of severe cases 1, 4
  • Pepper spray (oleoresin capsicum) is an irritant that causes temporary effects but can lead to significant discomfort 5

Common Pitfalls to Avoid

  • Delaying irrigation - immediate decontamination is critical to minimize tissue damage 1
  • Cross-contaminating the unaffected eye or other individuals during treatment 1