Safe Use of Prochlorperazine in Elderly Patients

Dosing and Administration

• The American Academy of Family Physicians recommends starting at the low end of the dosing range in elderly patients, with a maximum dosing of 25 mg orally or by suppository, maximum three doses per 24 hours, for acute nausea and vomiting 1

Drug Interactions and Precautions

• The National Comprehensive Cancer Network recommends avoiding combining prochlorperazine with other dopamine antagonists, such as metoclopramide or haloperidol, to prevent excessive dopamine blockade 2