Antiemetic Therapy with Promethazine Rectal Suppositories

Alternative Antiemetic Options

• The American Gastroenterological Association considers 5-HT3 receptor antagonists like ondansetron as more effective alternatives with less sedation for patients seeking non-sedating options 1
• Metoclopramide is a less sedating option than promethazine but requires monitoring for extrapyramidal symptoms 1
• In pregnancy-related nausea and vomiting, promethazine is considered after first-line therapies have failed, as recommended by the American College of Gastroenterology 2, 3

Important Considerations and Precautions

• The American College of Gastroenterology recommends monitoring for drug-induced extrapyramidal adverse effects, especially with prolonged use of promethazine 3