Safety of Cefepime in Patients with Augmentin Allergy

Understanding Cross-Reactivity and Safe Administration

Patients with immediate-type allergy to penicillins can safely receive cephalosporins with dissimilar side chains, regardless of severity and time since the reaction 1
Patients with non-severe, delayed-type allergy to penicillins can safely receive cephalosporins with dissimilar side chains 1, 2
If there are significant concerns about using cefepime, carbapenems are safe alternatives for patients with penicillin allergy 1, 2
Monobactams like aztreonam can also be safely used in patients with penicillin allergy without prior testing 1