Amantadine Dosage Considerations in Renal Impairment

Dosing Adjustments

• For patients with creatinine clearance ≤50 mL/min, dosage reduction is mandatory because amantadine is 90% excreted unchanged in urine, according to the MMWR Recommendations and Reports 1
• Elderly patients (≥65 years) should not exceed 100 mg daily due to age-related decline in renal function, as recommended by the MMWR Recommendations and Reports 1

Safety Profile

• Patients with renal insufficiency, seizure disorders, or psychiatric disorders require closer monitoring and lower doses, as suggested by the Journal of the American Academy of Child and Adolescent Psychiatry and the MMWR Recommendations and Reports 1, 3
• Seizure incidence increases in patients with pre-existing seizure disorders, according to the MMWR Recommendations and Reports 4

Special Considerations

• The Centers for Disease Control and Prevention, as published in the MMWR Recommendations and Reports, recommends careful dose adjustment in patients with renal impairment to minimize the risk of adverse effects 1