Converting U-200 Insulin Degludec to U-100

Key Conversion Principles

• The U-200 formulation of insulin degludec has pharmacokinetics similar to the U-100 counterpart, meaning the biological effect per unit is identical 1
• The patient will inject a larger volume (0.6 mL vs 0.3 mL) but the same number of units 1

Monitoring During Transition

• Check blood glucose at least 4 times daily during adjustment period to identify any unexpected glycemic patterns 2

Dose Adjustment

• The recommended adjustment increment is typically 10-15% or 2-4 units per change 3, 4