Amlodipine and Statin Combination Therapy

Introduction to Combination Therapy

• The American Heart Association recommends combining amlodipine with most statin types without dose adjustment, as this combination is safe for most patients 1

Amlodipine With Different Statins

• Amlodipine can be coadministered with atorvastatin, pitavastatin, rosuvastatin, fluvastatin, and pravastatin without evidence of significant interaction and without requiring dose adjustments, according to the American Heart Association 1
• The combination of amlodipine and rosuvastatin is generally safe and well-tolerated with no significant pharmacokinetic interactions 2

Important Caveats

• Diltiazem and verapamil are not interchangeable with amlodipine, as they cause more significant interactions with statins, including a 5-fold increase in simvastatin AUC with diltiazem 1
• Diltiazem and verapamil require a maximum simvastatin dose of 10 mg daily due to potent interactions 3

Monitoring and Dose Adjustment

• Check liver enzymes and CPK to rule out hepatotoxicity or myopathy caused by statins when coadministered with amlodipine 2