Effect of Vitamin D on PSA Levels in Prostate Cancer

Evidence on Vitamin D and PSA

Preliminary research suggests that vitamin D supplementation may reduce PSA levels in some prostate cancer patients, though the evidence is limited and results are mixed 1
Two preliminary studies indicate that vitamin D may reduce prostate-specific antigen (PSA) levels, either when given alone or in conjunction with chemotherapy, though further research is needed to determine the full effect of this treatment 1, 2, 3
A small study examining flaxseed (a source of lignan phytoestrogens) showed some potentially beneficial effects on PSA levels in prostate cancer survivors, though it's unclear if these findings translate to better prognoses 1, 2, 3

The National Osteoporosis Foundation recommends supplemental calcium (1200 mg/day) and vitamin D3 (800-1000 IU/day) for all men >50 years of age undergoing androgen-suppressive therapy who are at high risk for osteoporosis 4, 5
Monitoring serum 25-hydroxy vitamin D levels may be appropriate when DEXA scans are performed, as recommended by the National Comprehensive Cancer Network 5
Vitamin D supplementation should be considered in the context of bone health rather than as a primary treatment for prostate cancer or PSA management, according to the National Comprehensive Cancer Network 4, 5