Praxis Medical Insights

Est. 2024 • Clinical Guidelines Distilled

Made possible by volunteer editors from the University of Calgary & University of Alberta

Last Updated: 8/30/2025

Common Cocci Bacteria Associated with UTI

Major Cocci Bacteria in UTIs

  • Enterococcus species and Staphylococcus saprophyticus are the most common cocci bacteria associated with urinary tract infections, with S. saprophyticus being the second most common cause of UTIs in young women after E. coli 1, 2
  • Coagulase-negative staphylococci are frequently found in both men and women with asymptomatic bacteriuria 1, 2
  • Group B streptococci can be found in asymptomatic bacteriuria, particularly in women 1
  • Enterococcus species are common in complicated UTIs and catheter-associated infections 3

Epidemiology and Clinical Significance

  • Enterococcus species are more commonly associated with complicated UTIs 3
  • Enterococcus species are frequently found in catheter-associated UTIs 3
  • Enterococcus species are often seen in patients with structural abnormalities of the urinary tract 3
  • Enterococcus species may be present in healthcare-associated infections 3

Clinical Considerations

  • Urine culture remains the gold standard for identifying the specific bacterial pathogen 4
  • For cocci bacteria, a colony count of ≥50,000 CFUs/mL is generally considered significant in symptomatic patients 4

Special Populations

  • Enterococcus species are among the most common organisms in catheter-associated UTIs 3
  • Patients with indwelling catheters acquire bacteriuria at a rate of 3-8% per day 3
  • Coagulase-negative staphylococci are common in catheterized patients 1
  • 25-50% of elderly women and 15-40% of elderly men in long-term care facilities have bacteriuria, often with mixed flora including gram-positive cocci 1
  • The clinical assessment of bacteriuria in elderly patients can be challenging, as symptoms may be atypical 1
  • Coagulase-negative staphylococci are common in men with UTIs, in addition to gram-negative bacilli and Enterococcus species 2

Antimicrobial Resistance Considerations

  • Local antimicrobial resistance patterns should guide empiric therapy choices 5
  • Enterococcus species may exhibit resistance to multiple antibiotics, particularly in healthcare settings 3