Praxis Medical Insights

Est. 2024 • Clinical Guidelines Distilled

Made possible by volunteer editors from the University of Calgary & University of Alberta

Last Updated: 9/30/2025

Conditions That Can Trigger Anxiety Attacks

Medical Conditions That Mimic or Trigger Anxiety

  • Hyperthyroidism can cause anxiety symptoms due to excessive thyroid hormone, affecting patients with this condition 2
  • Hypoglycemia and diabetes can trigger panic-like symptoms in individuals with these conditions due to blood sugar fluctuations 2
  • Cardiac arrhythmias and other heart disorders can initiate or mimic panic attacks in patients with these conditions, causing palpitations and chest discomfort 2
  • Asthma can overlap with panic symptoms, presenting with shortness of breath and respiratory distress in individuals with this condition 2
  • Migraines can present with anxiety and autonomic symptoms, affecting patients with this condition 2
  • Chronic pain conditions can trigger anxiety in individuals with persistent pain 2

Substance-Induced Anxiety

  • Caffeine excess can directly provoke anxiety and panic in individuals who consume high amounts of caffeine 2
  • Medications can induce anxiety as a side effect in patients taking various prescription drugs 1, 2
  • Illicit drug use can trigger anxiety in individuals using stimulants or experiencing withdrawal states 1
  • Alcohol and substance withdrawal can create rebound anxiety and panic in individuals undergoing withdrawal 1

Psychiatric Comorbidities as Triggers

  • 56% of patients with major depressive disorder have comorbid anxiety, significantly increasing suicide risk in this population 1, 4
  • Sexual harassment, assault, and trauma are common underlying triggers of anxiety in women, particularly those with a history of trauma 1, 4
  • PTSD frequently manifests as anxiety symptoms, affecting individuals with this condition 1
  • Bipolar disorder, ADHD, obsessive-compulsive disorder, eating disorders, and substance use disorders can trigger anxiety in individuals with these conditions 5

Psychosocial and Environmental Triggers

  • School performance worries, concerns about physical appearance, earlier sexualization pressures, changing media and consumer culture exposure, poor self-esteem, and social media comparison effects can trigger anxiety in adolescent girls and women 1
  • Stressful or traumatic life events can directly precipitate anxiety episodes in individuals who experience these events 2
  • Insecure attachment patterns can increase vulnerability to anxiety in individuals with these patterns 2
  • Peer rejection and social skills deficits can trigger social anxiety in individuals with these issues 2
  • Anxiogenic parenting behaviors, such as overprotective or controlling parenting styles, can perpetuate anxiety in children 2
  • Family history, with 30-50% heritability, indicates genetic vulnerability to anxiety in individuals with a family history of anxiety disorders 1, 4

Developmental and Biological Vulnerabilities

  • Behavioral inhibition in childhood, characterized by temperamental fearfulness, predicts later anxiety in individuals with this trait 2, 5
  • Autonomic hyperreactivity, marked by exaggerated physiological stress responses, can contribute to anxiety in individuals with this condition 2
  • Negative affectivity, or a tendency toward negative emotional states, can increase the risk of anxiety in individuals with this trait 2, 5

Pregnancy and Postpartum Period

  • Anxiety disorders increase in frequency and severity during pregnancy and postpartum, affecting the mother, infant, and family, and requiring heightened vigilance during this period 1, 4