Ondansetron-Induced Extrapyramidal Symptoms

Risk Factors and Clinical Significance

• Pediatric patients may be at higher risk for medication side effects including EPS, according to the American Academy of Child and Adolescent Psychiatry 1

Comparison to Other Antiemetics

• Metoclopramide and phenothiazines have much higher rates of drug-induced extrapyramidal adverse effects, as reported by the American Gastroenterological Association 2

Clinical Implications

• Healthcare providers should monitor patients closely after ondansetron administration, particularly those with risk factors, as suggested by clinical guidelines 3