Cephalexin Dosing for Skin Abrasion

Adult Dosing Recommendations

The standard oral dose of cephalexin for skin and soft tissue infections, including skin abrasions, is 500 mg three times daily for adults, as recommended by the Infectious Diseases Society of America 1, 2
For more severe infections, the dose may be increased to 500 mg four times daily, with a strength of evidence based on clinical guidelines from the Infectious Diseases Society of America 2, 3

The typical treatment duration for uncomplicated skin infections is 7 days, depending on clinical response, according to the Infectious Diseases Society of America 3
If the infection has not improved within 5 days, treatment should be extended, as recommended by the Infectious Diseases Society of America 4

Cephalexin is effective against common pathogens causing skin infections, including Staphylococcus aureus and Streptococcus species, with a high level of evidence from the Infectious Diseases Society of America 3, 4
Cephalexin has good activity against staphylococci and streptococci but limited activity against Pasteurella multocida and anaerobes, as reported by the Infectious Diseases Society of America 1, 2
For simple skin abrasions without signs of significant infection, topical antimicrobial agents may be sufficient, according to the Infectious Diseases Society of America 4

If systemic signs of infection develop, consider broadening antimicrobial coverage, as recommended by the Infectious Diseases Society of America 4, 5

Cephalexin is not effective against MRSA; if MRSA is suspected or confirmed, alternative agents should be considered, according to the Infectious Diseases Society of America 3, 4

Patients with a history of immediate hypersensitivity to penicillin should be cautious when using cephalexin, as there may be cross-reactivity with cephalosporins, according to the American Academy of Family Physicians 6