Gastroesophageal Reflux Disease (GERD) Management and Pregabalin

Introduction to GERD and Pregabalin

The American Gastroenterological Association (AGA) does not list pregabalin as a cause of GERD or as a medication that exacerbates GERD symptoms, instead discussing GABA-B agonists like baclofen as potential adjunctive therapy for GERD in specific circumstances 1

Common medications associated with GERD include NSAIDs, Acetylsalicylic acid, Calcium channel blockers, Nitrates, Some antidepressants, Benzodiazepines, Anticholinergics, and Theophylline, but pregabalin is not among them 1

The American Gastroenterological Association (AGA) recommends GERD management to include lifestyle modifications, PPI therapy, and adjunctive therapies such as H2 receptor antagonists, alginates, prokinetics, and baclofen for specific indications 1
Current guidelines also suggest considering other common causes of GERD, evaluating for other medications that may be known GERD triggers, and implementing standard GERD management approaches if a patient taking pregabalin develops GERD symptoms 2, 3

Pregabalin may actually have beneficial effects on certain gastrointestinal conditions, such as functional dyspepsia and visceral hypersensitivity, although the evidence is still emerging 1