Praxis Medical Insights

Est. 2024 • Clinical Guidelines Distilled

Made possible by volunteer editors from the University of Calgary & University of Alberta

Last Updated: 9/21/2025

Treatment of Malignant Rectovaginal Fistula

Introduction to Malignant Rectovaginal Fistula Treatment

  • For malignant rectovaginal fistulas, surgical resection with oncologic principles is the definitive treatment when curative intent is possible, while fecal diversion provides palliation for patients who cannot undergo resection 1

Critical Distinction: Malignant vs. Inflammatory Fistulas

  • Medical therapy with anti-TNF agents has no role in malignant fistulas and should not delay definitive oncologic treatment, as recommended by the American Gastroenterological Association 2

Curative Treatment Approach

  • Oncologic resection is the cornerstone of curative treatment for malignant rectovaginal fistulas, with a high success rate, according to the American Society of Colon and Rectal Surgeons 1

Critical Pitfalls to Avoid

  • Never attempt local repair procedures (advancement flaps, sphincteroplasty) for malignant fistulas, as these are contraindicated and will fail, as stated by the American Gastroenterological Association 2