Praxis Medical Insights

Est. 2024 • Clinical Guidelines Distilled

Made possible by volunteer editors from the University of Calgary & University of Alberta

Last Updated: 8/29/2025

Treatment of Depression with Caplyta

Clinical Considerations and Monitoring

  • The American College of Physicians recommends assessing patient status, therapeutic response, and adverse effects of antidepressant therapy regularly beginning within 1-2 weeks of initiation 1, 2
  • If patients do not have an adequate response to pharmacotherapy within 6-8 weeks, treatment modification should be considered 3
  • For patients with a first episode of major depressive disorder, treatment should continue for 4-9 months after a satisfactory response 4