Stress-Induced Leukocytosis

Mechanisms and Implications

• The spleen is a source of mobilized leukocytes during stress, including granulocytes 1
• Effective stress management can help normalize white blood cell counts in patients with stress-induced leukocytosis, as recommended by the American Academy of Family Physicians 2

Clinical Considerations

• Chronic stress can contribute to a vicious cycle of metabolic and immunological alterations that worsen various medical conditions, with evidence from Reviews in Endocrine and Metabolic Disorders 1