Ciprofloxacin Dosing for UTI in End-Stage Renal Disease on Hemodialysis

Specific Dosing Recommendations

The Centers for Disease Control and Prevention, as reported in MMWR Recommendations and Reports, and the Infectious Diseases Society of America, as reported in Clinical Infectious Diseases, recommend administering ciprofloxacin after dialysis on dialysis days for patients with UTI and end-stage renal failure on hemodialysis, with a dose range of 250-500 mg every 24 hours 1, 2
Administering ciprofloxacin after dialysis is critical because it is partially removed during hemodialysis, and post-dialysis administration prevents premature drug removal, as stated in guidelines from the MMWR Recommendations and Reports and Clinical Infectious Diseases 1, 2

The Centers for Disease Control and Prevention, as reported in MMWR Recommendations and Reports, and the Infectious Diseases Society of America, as reported in Clinical Infectious Diseases, advise against dosing ciprofloxacin before dialysis, as this results in premature drug removal and subtherapeutic levels 1, 2