Management of Prediabetes with Metformin

Monitoring and Targets

• The American Diabetes Association recommends checking A1C every 3 months to assess glycemic response 1
• The target A1C should be <6.5% for most patients with prediabetes 2

Lifestyle Modifications

• The American Diabetes Association recommends lifestyle modifications accompanying metformin therapy, including 150+ minutes of moderate-to-vigorous physical activity weekly, healthy eating patterns focusing on nutrient-dense foods, and weight loss of 7-10% if overweight/obese 1, 2

Treatment Approach

• The American College of Clinical Endocrinologists suggests that metformin is appropriate for patients with prediabetes and an A1C ≥ 6.0%, as medication intervention shows greater benefit in this higher risk category 1, 2