Praxis Medical Insights

Est. 2024 • Clinical Guidelines Distilled

Made possible by volunteer editors from the University of Calgary & University of Alberta

Last Updated: 8/28/2025

Low-Carb Diet Considerations

Non-Nutritive Sweeteners

  • Non-nutritive sweeteners can reduce overall calorie and carbohydrate intake when substituted for sugar, but should be viewed as a short-term replacement strategy rather than a long-term solution, according to the American Diabetes Association 1, 2
  • Research suggests potential impacts of artificial sweeteners on cognitive processes, oral-gastrointestinal taste receptors, glucose-insulin homeostasis, metabolic hormones, and gut microbiome, as reported by the American Heart Association 3, 4

Very Low-Carb Ketogenic Diet

  • For those following a very low-carbohydrate ketogenic diet (VLCKD) containing less than 50g of carbohydrate per day, natural non-caloric sweeteners like stevia and monk fruit are particularly suitable, as recommended by the American College of Nutrition 5
  • VLCKD requires careful monitoring, especially for those taking diabetes medications, as insulin sensitivity often improves, necessitating medication adjustments to prevent hypoglycemia, according to the American Association of Clinical Endocrinologists 5

Practical Recommendations

  • Consider moderate carbohydrate intake (44-46% of total calories) as potentially more sustainable and safer long-term than very restrictive approaches, as suggested by the Academy of Nutrition and Dietetics 5
  • When choosing grain products alongside low-carb sweeteners, look for those with a ratio of total carbohydrate to dietary fiber of <10:1 as a practical guide to identify more healthful options, as recommended by the American Heart Association 6
  • Water should be emphasized as the primary beverage, with sweetened beverages (even those with non-nutritive sweeteners) reduced overall, according to the American Diabetes Association 2