Monitoring of Levetiracetam

Introduction to Monitoring

• The American Gastroenterological Association recommends monitoring complete blood count when levetiracetam is used as a prophylactic therapy, with no need for therapeutic drug monitoring 1

Special Populations

• No specific citation is provided for special population monitoring, however, it is noted that certain populations may benefit from individualized monitoring, including critically ill patients, elderly patients, pediatric patients, pregnant women, and patients with renal impairment

Clinical Scenarios

• The National Comprehensive Cancer Network recommends no specific monitoring for levetiracetam when used as seizure prophylaxis in CAR T-cell therapy 2

Comparison to Other Antiepileptic Drugs

• The American Academy of Child and Adolescent Psychiatry recommends regular monitoring of serum drug levels, hepatic and hematological indices for valproate, and regular monitoring of lithium levels, renal and thyroid function for lithium 4
• Note that topiramate requires regular monitoring of serum electrolytes, renal function, and liver function tests, however this fact is from 'Praxis Medical Insights' and a more suitable citation is not provided 3