Antibiotic Treatment for Providencia rettgeri Infections

Antibiotic Options

Ceftazidime-avibactam 2.5g IV q8h is recommended for complicated urinary tract infections caused by carbapenem-resistant Enterobacterales (CRE) according to the Journal of Microbiology, Immunology and Infection 1, 2
Meropenem-vaborbactam 4g IV q8h or imipenem-cilastatin-relebactam 1.25g IV q6h are alternatives for CRE infections 2, 3
Aminoglycosides can be effective for urinary tract infections caused by P. rettgeri, with single-dose aminoglycoside recommended for simple cystitis due to resistant strains 2, 4
Plazomicin 15 mg/kg IV q12h is recommended for complicated UTI due to resistant Enterobacterales 2

Ceftazidime-avibactam 2.5g IV q8h infused over 3 hours is recommended for carbapenem-resistant bloodstream infections 3
For intra-abdominal infections caused by carbapenem-resistant strains, ceftazidime-avibactam 2.5g IV q8h in combination with metronidazole is recommended 2
Tigecycline (100mg IV loading dose then 50mg IV q12h) or eravacycline (1mg/kg IV q12h) are alternatives for intra-abdominal infections 2

For severe infections with limited treatment options, combination therapy may be considered for carbapenem-resistant strains 3