Ozempic Contraindications and Thyroid Concerns

Absolute Contraindications

The American College of Cardiology indicates that a personal history of medullary thyroid carcinoma (MTC) is an absolute contraindication for Ozempic use 1
The American College of Cardiology also states that a family history of medullary thyroid carcinoma is an absolute contraindication for Ozempic use 1
The American College of Cardiology notes that Multiple Endocrine Neoplasia syndrome type 2 (MEN2) is an absolute contraindication for Ozempic use 1

The American College of Cardiology guidelines suggest that primary hypothyroidism, hyperthyroidism, and autoimmune thyroid disease are not contraindications to Ozempic use, with the exception of MTC and MEN2 1
Patients with Hashimoto's thyroiditis can use Ozempic, according to the Annals of Internal Medicine 2
Patients with Graves' disease (treated and controlled) can use Ozempic, as per the Annals of Internal Medicine 2

Ozempic is contraindicated in patients with a personal or family history of medullary thyroid carcinoma (MTC) or in patients with Multiple Endocrine Neoplasia syndrome type 2 (MEN2), as stated by the American College of Cardiology guidelines 3

The American College of Cardiology guidelines note a 38% higher risk of serious adverse events with semaglutide versus placebo 4
Semaglutide is associated with adverse effects including gastrointestinal disturbances, risk of pancreatitis, gallbladder disease, and diabetic retinopathy complications, according to the Gastroenterology journal 4