Management of Deep Vein Thrombosis

Initial Treatment

• Initial anticoagulation with low molecular weight heparin (LMWH), fondaparinux, or unfractionated heparin should be started immediately, followed by transition to oral anticoagulation, as recommended by the American College of Chest Physicians 1, 2, 3, 4

Acute Phase Treatment

• Start parenteral anticoagulation (LMWH, fondaparinux, IV unfractionated heparin, or SC unfractionated heparin) immediately upon diagnosis, according to the American College of Chest Physicians 1, 2
• LMWH or fondaparinux is preferred over IV unfractionated heparin for acute DVT, as stated by the American College of Chest Physicians 1, 3
• Early initiation of vitamin K antagonist (same day as parenteral therapy) with continuation of parenteral anticoagulation for minimum 5 days and until INR ≥2.0 for at least 24 hours, as recommended by the American College of Chest Physicians 1, 2