Treatment of Antibiotic-Associated Diaper Rash in Infants

Immediate Management

• The British Journal of Dermatology recommends cleaning the diaper area with emollient ointment rather than water or commercial wipes, as wipes can further irritate compromised skin, and to avoid rubbing; use gentle patting motions 1, 2
• Consider trimming inner elastic bands to reduce friction and line diapers with soft cloth liners coated with emollient or paraffin-impregnated gauze, as suggested by the British Journal of Dermatology 1, 2

Critical Pitfalls to Avoid

• The British Journal of Dermatology advises against using commercial wipes on inflamed skin, as they contain chemicals that worsen irritation, and to avoid rubbing or aggressive cleansing that causes further trauma 1, 2

Adverse Events

• According to Praxis Medical Insights, antibiotics cause approximately 5% increased rate of adverse events including diarrhea and rash, with high-dose amoxicillin-clavulanate showing 44% adverse event rates 3