Dosing of Augmentin in Dialysis Patients

Dosing Considerations

• Medications for dialysis patients should be administered after the dialysis session to prevent premature removal of the drug 1
• Standard dosing of antibiotics is inappropriate for patients with end-stage renal disease as it can lead to drug accumulation and toxicity 1
• The interval between drug doses in patients with a creatinine clearance of <30 mL/minute and those receiving hemodialysis should be increased rather than decreasing the dose 1

Administration Schedule

• The medication should be given after the dialysis session on dialysis days 1

Duration of Therapy

• For complicated UTIs, the recommended duration of treatment is typically 7-14 days, though this may need to be individualized based on clinical response 2

Common Pitfalls to Avoid

• Do not administer the medication before dialysis as this would lead to premature removal of the drug and subtherapeutic levels 1