Safety of Combining Vyvanse (Lisdexamfetamine) and Pristiq (Desvenlafaxine)

Pharmacological Considerations

• Lisdexamfetamine is a prodrug stimulant that is converted to dextroamphetamine after ingestion, used primarily for ADHD treatment 1

Safety Profile of the Combination

• While neither medication alone significantly increases serotonin syndrome risk, caution should be exercised when combining serotonergic medications, as recommended by the American Academy of Child and Adolescent Psychiatry 2