Praxis Medical Insights

Est. 2024 • Clinical Guidelines Distilled

Made possible by volunteer editors from the University of Calgary & University of Alberta

Last Updated: 11/7/2025

Prostaglandin Analog Eye Drops for Glaucoma Treatment

Introduction to Prostaglandin Analogs

  • The American Academy of Ophthalmology recommends prostaglandin analogs as first-line therapy for primary open-angle glaucoma due to their superior IOP-lowering efficacy 1

Clinical Efficacy

  • Prostaglandin analogs are recommended as first-line therapy for primary open-angle glaucoma based on their superior IOP-lowering efficacy, as suggested by the American College of Physicians 1, 2

Less Commonly Used Agents

  • Unoprostone 1.2 mg/ml is less effective than other prostaglandin analogs and requires twice-daily dosing, unlike other prostaglandins, according to the Annals of Internal Medicine 1

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