Pneumococcal Vaccine Recommendations

General Recommendations

The Centers for Disease Control and Prevention recommends that adults aged ≥65 years with no previous pneumococcal vaccination receive a single dose of PCV20 1, 2
For adults aged ≥65 years who previously received PPSV23 only, a single dose of PCV20 is recommended at least 1 year after the last PPSV23 dose 1, 3
The Centers for Disease Control and Prevention recommends that adults aged 19-64 years with immunocompromising conditions, CSF leaks, or cochlear implants receive a single dose of PCV20 1, 2

High-risk individuals, such as those with functional or anatomic asplenia, HIV infection, or other immunosuppressive conditions, should receive revaccination once if 5 years have elapsed since the first dose 4, 5
Hematopoietic Stem Cell Transplant (HSCT) recipients should receive 3 doses of PCV20, 4 weeks apart starting 3-6 months after HSCT, followed by a fourth PCV20 dose ≥6 months after the third dose or ≥12 months after HSCT, whichever is later 6, 7, 2

PCV20 can be administered at the same visit as other age-appropriate vaccines at different anatomic sites 2
For patients who have received PCV15 but have not completed their recommended pneumococcal vaccine series with PPSV23, one dose of PCV20 may be used if PPSV23 is not available 2
Revaccination is contraindicated for persons who had a severe reaction to the initial dose 4, 5

Failing to check the patient's prior pneumococcal vaccination history can lead to unnecessary doses or incorrect vaccination schedules 2
Withholding vaccination in the absence of an immunization record is not recommended, and the patient's verbal history should be used to determine prior vaccination status 4, 5