Praxis Medical Insights

Est. 2024 • Clinical Guidelines Distilled

Made possible by volunteer editors from the University of Calgary & University of Alberta

Last Updated: 8/26/2025

Management of Myasthenia Gravis

Medication Considerations

  • Patients with Myasthenia gravis should avoid Beta-Blockers, IV-Magnesium, Fluorchinolone, Aminoglykoside, and Makrolid-Antibiotika, as these medications can worsen myasthenic symptoms and potentially trigger a myasthenic crisis, according to Praxis Medical Insights 1

Treatment Options

  • Pyridostigminbromid, administered orally two to four times daily, is the first-line treatment for Myasthenia gravis, but approximately half of patients with strabismus-associated Myasthenia show only minimal response, as reported by the American Academy of Ophthalmology 2, 3
  • Approximately 66% to 85% of patients show a positive response to Corticosteroids, as reported by the American Academy of Ophthalmology 2, 3
  • Various forms of immunosuppressive therapy with Azathioprin and other agents may be offered by treating neurologists, as reported by the American Academy of Ophthalmology 2, 3
  • Thymectomy is indicated in some cases, always in the presence of a thymoma, and can significantly reduce symptoms in certain subgroups with Myasthenia gravis, as reported by the American Academy of Ophthalmology 2, 3

REFERENCES

1

Medications to Avoid in Myasthenia Gravis [LINK]

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2025