Causes of Low Uric Acid

Medication-Induced Hypouricemia

• Uricases, such as rasburicase, directly catabolize uric acid into allantoin, causing rapid and profound hypouricemia in patients, according to the American Society of Clinical Oncology 1
• Low-dose aspirin modestly affects uric acid levels, though the effect is variable, as reported by the American College of Rheumatology 2

Physiological Context

• Uric acid behaves as a negative acute phase reactant, temporarily decreasing during acute inflammation and stress, as noted by the European League Against Rheumatism 3
• Uric acid also behaves as a negative acute phase reactant, temporarily decreasing during acute inflammation and stress, with patients with gout may paradoxically having normal or low serum uric acid during acute attacks due to increased renal excretion, according to the European League Against Rheumatism 4