Praxis Medical Insights

Est. 2024 • Clinical Guidelines Distilled

Made possible by volunteer editors from the University of Calgary & University of Alberta

Last Updated: 6/13/2025

Adverse Effects of Venlafaxine

Introduction to Venlafaxine Adverse Effects

  • The American Academy of Child and Adolescent Psychiatry recommends that if venlafaxine needs to be discontinued due to skin reactions, it should be tapered gradually to avoid discontinuation syndrome 1

Management of Skin Reactions

  • When evaluating a patient with a late-onset skin rash who is taking venlafaxine, consider severity assessment, temporal relationship, and alternative causes, and for mild, localized rashes without systemic symptoms, monitor closely and consider symptomatic treatment, while for severe rashes, discontinue venlafaxine immediately and seek urgent medical evaluation 1

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