Praxis Medical Insights

Est. 2024 • Clinical Guidelines Distilled

Made possible by volunteer editors from the University of Calgary & University of Alberta

Last Updated: 9/6/2025

Quetiapine Dosage Recommendations

Introduction to Quetiapine

  • The American Academy of Family Physicians recommends an initial dosage of quetiapine (Seroquel) at 12.5 mg twice daily, with a maximum dosage of 200 mg twice daily for most indications 1

Monitoring and Administration

  • Monitor for orthostatic hypotension, especially during initial dose titration, as recommended by the American family physician 1
  • The American family physician notes that quetiapine can cause sedation and orthostatic hypotension, and recommends caution when administering the medication 1