Meningococcal A and B Vaccines Administration Guidelines

Rationale for Simultaneous Administration

The Advisory Committee on Immunization Practices (ACIP) guidelines indicate that MenACWY and MenB vaccines can be administered at the same visit, though they must be given at different anatomic sites 2, 3
Simultaneous administration of indicated vaccines increases the likelihood of complete vaccination and provides timely protection against meningococcal disease 1
The immune response to these vaccines is not affected when they are administered together, allowing for concurrent administration without compromising efficacy 1

When administering both vaccines at the same visit, use different anatomic sites (e.g., left and right arms) 3
Do not mix the vaccines in the same syringe 1
Document each vaccine in the patient's permanent medical record 1
MenB vaccine products (MenB-FHbp and MenB-4C) are not interchangeable; the same product must be used for all doses in a series 2, 4

For healthy adolescents and young adults, MenACWY is routinely recommended at age 11-12 years with a booster at age 16 years 5
MenB vaccination for ages 16-23 years is based on shared clinical decision-making for those without specific risk factors 6
For persons with complement deficiencies, using complement inhibitors, or with anatomic/functional asplenia: MenACWY should be given as 2 doses ≥8 weeks apart with boosters every 5 years, and MenB should be given as either a 3-dose MenB-FHbp series or a 2-dose MenB-4C series with boosters every 2-3 years 4

During meningococcal outbreaks, vaccination recommendations may change based on the specific serogroup causing the outbreak 8
For international travelers to high-risk areas, both MenACWY and MenB may be indicated and can be administered simultaneously 9