GABAergic Medications for Various Conditions

Benzodiazepines

The American Academy of Sleep Medicine recommends lorazepam for anxiety, insomnia, status epilepticus, alcohol withdrawal, and agitation in delirium, with a dosing of 1mg SC/IV for acute management and 0.5-2mg orally for scheduled dosing 1, 2
The American Family Physician suggests temazepam for short-term treatment of insomnia, with a dosing of 15-30mg at bedtime and 7.5mg in elderly or debilitated patients 2, 4

The National Comprehensive Cancer Network recommends gabapentin for postherpetic neuralgia and adjunctive therapy for partial seizures, with a starting dose of 100-300mg at bedtime and increasing to 900-3600mg/day in divided doses 6, 7
The Journal of the National Comprehensive Cancer Network suggests pregabalin for neuropathic pain, fibromyalgia, and adjunctive therapy for partial seizures, with a starting dose of 50mg three times daily and increasing to 100mg three times daily 7

The American Academy of Sleep Medicine recommends baclofen for spasticity, trigeminal neuralgia, and alcohol use disorder, with a dosing of 5mg three times daily initially and titrated up as needed 3, 5
The BMJ suggests sodium oxybate for narcolepsy and alcohol withdrawal, with special considerations for controlled substance abuse potential 8

The Journal of Clinical Sleep Medicine recommends non-benzodiazepine receptor agonists or intermediate-acting benzodiazepines for short-term use in insomnia 4
The Journal of the National Comprehensive Cancer Network suggests gabapentinoids as first-line options for neuropathic pain, often requiring gradual titration to effective doses 6, 7
The Clinical and Molecular Hepatology recommends benzodiazepines as the treatment of choice for alcohol withdrawal, with lorazepam preferred in patients with liver disease 3
The Journal of the American Geriatrics Society recommends lower starting doses for all GABAergic medications in elderly patients due to increased sensitivity and risk of adverse effects 4, 5