Ceftazidime-Avibactam with Aztreonam for Complicated Infections

Dosing Recommendations by Infection Type

For complicated intra-abdominal infections, the Infectious Diseases Society of America recommends ceftazidime-avibactam 2.5 g IV q8h (infused over 2 hours) + metronidazole 500 mg q6h 1
The treatment duration for complicated intra-abdominal infections is 5-7 days, individualized based on source control and clinical response, as recommended by the Infectious Diseases Society of America 2, 1
For complicated urinary tract infections, the European Society of Clinical Microbiology and Infectious Diseases recommends ceftazidime-avibactam 2.5 g IV q8h (infused over 2 hours) 1
The treatment duration for complicated urinary tract infections is 5-7 days, as recommended by the European Society of Clinical Microbiology and Infectious Diseases 1, 3
For carbapenem-resistant Enterobacterales, the Centers for Disease Control and Prevention recommends ceftazidime-avibactam as a treatment option 4, 5

For bloodstream infections, the Infectious Diseases Society of America recommends ceftazidime-avibactam 2.5 g IV q8h (infused over 2 hours) 1, 3
The treatment duration for bloodstream infections is 7-14 days, as recommended by the Infectious Diseases Society of America 1, 3
For CRE bloodstream infections, the Infectious Diseases Society of America recommends ceftazidime-avibactam with a weak recommendation (2D) 4

Treatment duration should be individualized based on infection site, source control, underlying comorbidities, and initial response to therapy, as recommended by the Infectious Diseases Society of America 2, 1

For pediatric patients, weight-based dosing is recommended with maximum dose limits, including 50 mg/kg/dose (ceftazidime component) IV every 8 hours for children ≥6 months, with a maximum dose of 2000 mg ceftazidime per dose, and 40 mg/kg/dose IV every 8 hours for children 3 to <6 months 6