Vibegron Treatment for Overactive Bladder

Treatment Approach

The American Urological Association and the Society of Urodynamics, Female Pelvic Medicine & Urogenital Reconstruction support the use of β3-adrenoceptor agonists like vibegron as an effective treatment option for overactive bladder 5
First-line therapy for overactive bladder includes behavioral interventions, such as bladder training, pelvic floor exercises, and fluid management, as recommended by the American Urological Association 1

For patients who do not respond to first-line therapy, pharmacological treatment with vibegron 75 mg once daily may be considered, with the option to combine with an antimuscarinic agent for inadequate response 2, 3, 4
The use of vibegron offers advantages over antimuscarinic agents, particularly for elderly patients, due to its lower risk of anticholinergic side effects like dry mouth, constipation, and cognitive impairment, as noted by the American Geriatrics Society 1

Regular assessment of symptom improvement and potential adverse effects is necessary when using vibegron, as recommended by the American Urological Association 5
Vibegron has demonstrated efficacy similar to mirabegron, another β3-adrenoceptor agonist, but with potentially fewer drug interactions, according to the European Association of Urology 6