Corticosteroid Conversion and Clinical Applications

Clinical Guidelines and Evidence

• The European Society of Gastroenterology recommends that 60 mg methylprednisolone daily is considered equivalent to higher doses of hydrocortisone for acute severe ulcerative colitis (ASUC) treatment 1, 2
• Maintaining equivalent anti-inflammatory potency is crucial when switching between corticosteroid medications, such as methylprednisolone and prednisone, for managing conditions requiring corticosteroid therapy 3

Pharmacological Properties

• Methylprednisolone has less mineralocorticoid effect than hydrocortisone at equivalent anti-inflammatory doses, resulting in significantly less hypokalaemia 1