Praxis Medical Insights

Est. 2024 • Clinical Guidelines Distilled

Made possible by volunteer editors from the University of Calgary & University of Alberta

Last Updated: 9/15/2025

Management of Sore Throat Caused by Chlorhexidine Mouthwash

Symptomatic Relief Options

  • The British Journal of Dermatology recommends applying an anti-inflammatory oral rinse or spray containing benzydamine hydrochloride every 3 hours, particularly before eating 3
  • The British Journal of Dermatology suggests applying white soft paraffin ointment to the lips every 2 hours if there is associated lip irritation 3
  • Warm saline mouthwashes can be used to cleanse and soothe the throat, as recommended by the British Journal of Dermatology 3

Oral Rinses

  • The Annals of Oncology guidelines state that chlorhexidine should not be restarted as it is not recommended for treatment of established oral mucositis or sore throat 5, 6, 7

Prevention of Future Episodes

  • The Praxis Medical Insights guidelines recommend maintaining good oral hygiene with a soft toothbrush or swab after meals 4
  • The Praxis Medical Insights guidelines suggest avoiding potential irritants such as smoking, alcohol, spicy foods, and hot beverages 4