Praxis Medical Insights

Est. 2024 • Clinical Guidelines Distilled

Made possible by volunteer editors from the University of Calgary & University of Alberta

Last Updated: 9/6/2025

Management of Side Effects with Progestin-Only Pills

Counseling and Effectiveness

  • The Centers for Disease Control and Prevention recommends that if unscheduled spotting or bleeding persists and is unacceptable to the patient, consider alternative contraceptive methods 1
  • The Centers for Disease Control and Prevention suggests that enhanced counseling about expected bleeding patterns and reassurance that these irregularities are generally not harmful can reduce method discontinuation 2
  • Approximately 9 out of 100 women become pregnant in the first year of use with typical use of progestin-only pills, according to the Centers for Disease Control and Prevention 2
  • The American Academy of Pediatrics advises that progestin-only pills work primarily by thickening cervical mucus and may not always inhibit ovulation 3
  • The Centers for Disease Control and Prevention recommends consistent and correct use of condoms for STD protection, as progestin-only pills do not protect against sexually transmitted diseases 2

Special Considerations

  • The American Academy of Dermatology notes that progestin-only pills may interfere with the contraceptive effect of microdosed progestin minipills 4