SMA Type 3 Fatigue and Sickness After High-Energy Activity

Pathophysiological Mechanisms

• Chronic malnutrition and negative nitrogen balance, common in SMA patients due to functional limitations affecting eating and metabolism, contribute to post-exertional exhaustion, as noted by Gut Microbes 1

Clinical Implications and Management Considerations

• Screen for respiratory insufficiency and nutritional deficits as contributing factors to post-exertional symptoms, as recommended by Gut Microbes 1