Subcutaneous Injection of Filgrastim

Route of Administration

• The National Comprehensive Cancer Network recommends the subcutaneous route as the preferred method of administration for filgrastim, with intravenous administration being technically possible but not the standard approach 1, 2, 3
• The American Society of Clinical Oncology emphasizes subcutaneous injection as the standard approach for filgrastim administration, with a strength of evidence based on multiple clinical trials 2, 4

Site Rotation

• The National Comprehensive Cancer Network and the American Society of Clinical Oncology recommend rotating injection sites to prevent local tissue irritation when administering multiple doses of filgrastim over several days, typically given daily at a dose of medication until neutrophil recovery 1, 2