Management of Bleeding Risk with Anticoagulant and Antidepressant Combination

Introduction to Bleeding Risk Management

• The American College of Cardiology recommends considering alternative anticoagulation strategies, such as left atrial appendage occlusion, in patients with atrial fibrillation and high bleeding risk, while continuing apixaban therapy 2

Medication Management Strategies

• The Anaesthesia guideline suggests discontinuing apixaban at least 3 days before high bleeding risk procedures if CrCl >30 mL/min, to minimize bleeding risk 1