Safest Antidepressant for Patients with Seizures on Keppra (Levetiracetam)

Important Safety Monitoring

• The American Academy of Child and Adolescent Psychiatry recommends seizure monitoring when using SSRIs in patients with seizure disorders, as the absolute risk is low 1
• The American Academy of Child and Adolescent Psychiatry suggests starting at lower doses and titrating gradually to minimize behavioral activation and other side effects 1
• The American Academy of Child and Adolescent Psychiatry advises avoiding combining SSRIs with MAOIs, tramadol, or multiple serotonergic agents due to the risk of serotonin syndrome 1
• The American Academy of Child and Adolescent Psychiatry recommends watching for behavioral activation, which is more common in younger patients and anxiety disorders, and may require dose reduction 1